Endocrine Abstracts

Increased fatty acid (FA) concentration is implicated in the development of insulin resistance (IR) in tissues such as the kidney. Research indicates the protective role of glucagon-like peptide (GLP)-1 receptor agonists; GLP-1 (7-36) amide and incretin mimetic; liraglutide, against IR. We aimed to induce IR in HEK293T cells, using the three most abundantly consumed FAs; palmitate, oleate, and stearate, or in a combination termed POS. This model was used to assess the extent o...

Background: Paediatric emergency departments saw an unusual increased incidence and severity of DKA in children with new onset diabetes in the COVID pandemic. The DIMPLES study (Diabetes Mellitus in children and young people presenting to the Emergency Department during the SARS-CoV-2 pandemic) explored this using retrospective multicentre data from 49 EDs, providing a unique perspective of paediatric diabetes from the frontline.Methods: We compared the ...

Introduction: At the onset of type 1 diabetes mellitus (T1DM), children often experience a partial remission which is characterized by decreased insulin requirements. Usually, some exogenous insulin is still needed during this honeymoon phase. We present cases of 2 children with T1DM who had significantly extended periods where no exogenous insulin was required. Case 1: 12-year-old girl presented with fatigue and weight gain. HbA1c in primary care was 51 mmol/mol. BMI was +3 <...

Alkaline phosphatase (ALP) was discovered by Robert Robison, PhD in London in 1923. In New York in 1932, he added to his hypothesis that ALP functioned in skeletal calcification by liberating inorganic phosphate (Pi) for hydroxyapatite crystal formation, perhaps from a hexosephosphoric ester, some unknown factor also conditioning this process. In 1948 in Toronto, Canada, ‘hypophosphatasia’ (HPP) was coined by John C. Rathbun, MD to describe a unique rickets without r...

Case history: A 39 year old male patient presented via ambulance to our unit with a deliberate mixed overdose. He had a past medical history of type 2 diabetes mellitus, depression and hypertension. He had ingested an uknown amount of atenolol, dapagliflozin, ramipril, co-codamol with both cocaine and benzodiazepines detected in urine toxicology. On arrival to hospital, the patient had fluid refractory hypotension, with a systolic blood pressure of 70mmHg and HR 45BPM. Given t...

: A 78-year-old male with a background of renal cell carcinoma and bilateral adrenal metastasis presented with leg cramps and lethargy. He was on Prednisolone 10 mg od for immune therapy induced pneumonitis. Prior to commencing Prednisolone, he was on Dexamethasone 2 mg for 4 months for weight loss, nausea and vomiting. He underwent a Short Synacthen Test (SST) as his serum Na was low at 119 mmol/L (134–146). His SST showed a flat response with baseline and 30 minutes cor...

Cardiovascular diseases are the greatest cause of death globally. Obesity significantly increases the risk for the development of cardiovascular diseases. However research does not under stand the physiological and molecular connections of these diseases. We have identified that the hormone leptin in obesity plays a key role in elevating blood pressure in obesity. However recent findings in humans treated with leptin in the disease state of lipodystrophy, did not result in the...

Introduction: Graves’ disease is the commonest cause of thyrotoxicosis. If left untreated myriad of complications, chief among which are cardiac related morbidity and mortality might supervene.Case presentation: A 31-year-old man presented to the endocrine clinic of LAUTECH Teaching Hospital, Ogbomoso, Nigeria 19 months ago with features suggestive of hyperthyroidism and a diagnosis of thyrotoxicosis secondary to Graves’ disease was made. He wa...

Background: Pediatric patients with diabetes are required to adhere to strict regimens including blood glucose testing, insulin therapy, and dietary restrictions. Adequate glucose control is necessary to prevent acute and chronic complications. Testing Hemoglobin A1c (HgbA1c) provides a simple evaluation of diabetes control and compliance with therapy. Psychological factors (depression, anxiety) play a major role in pediatric diabetes compliance. Access to psychological suppor...

Insulin resistance and androgen excess, alongside anovulatory infertility, are the cardinal clinical and biochemical features of polycystic ovary syndrome (PCOS). Circulating androgen burden and metabolic dysfunction in PCOS are closely correlated, but an independent contribution of androgens per se to metabolic and other complications of PCOS remains poorly characterised. My work since 2012 has focused on delineating the distinct impact of androgens on metab...